Version 5.4
Bos taurus Protein: SNAP25
Summary
InnateDB Protein IDBP-688373.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SNAP25
Protein Name Synaptosomal-associated protein 25
Synonyms SNAP-25;
Species Bos taurus
Ensembl Protein ENSBTAP00000010961
InnateDB Gene IDBG-636453 (SNAP25)
Protein Structure
UniProt Annotation
Function t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, perinuclear region {ECO:0000250}. Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Cell junction, synapse, synaptosome {ECO:0000250}. Note=Membrane association requires palmitoylation. Expressed throughout cytoplasm, concentrating at the perinuclear region (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 31 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000149 SNARE binding
GO:0005515 protein binding
Biological Process
GO:0007269 neurotransmitter secretion
GO:0010975 regulation of neuron projection development
GO:0016192 vesicle-mediated transport
GO:0060291 long-term synaptic potentiation
GO:0070201 regulation of establishment of protein localization
Cellular Component
GO:0005737 cytoplasm
GO:0005802 trans-Golgi network
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030054 cell junction
GO:0030426 growth cone
GO:0031083 BLOC-1 complex
GO:0031201 SNARE complex
GO:0043005 neuron projection
GO:0045202 synapse
GO:0048471 perinuclear region of cytoplasm
GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex
Protein Structure and Domains
PDB ID
InterPro IPR000727 Target SNARE coiled-coil domain
IPR000928 SNAP-25
IPR010989 t-SNARE
PFAM PF05739
PF00835
PRINTS
PIRSF
SMART SM00397
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q17QQ3
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 540853
UniGene Bt.42529
RefSeq NP_001069714
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC118237
GenPept AAI18238

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca