InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: RGN

Summary

InnateDB Protein

IDBP-688411.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RGN

Protein Name

Regucalcin

Synonyms

GNL;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000055515

InnateDB Gene

IDBG-636485 (RGN)

Protein Structure

UniProt Annotation

Function

Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Catalyzes a key step in ascorbic acid (vitamin C) biosynthesis. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium-binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004341	gluconolactonase activity
GO:0005509	calcium ion binding
GO:0008270	zinc ion binding
GO:0016787	hydrolase activity
GO:0030234	enzyme regulator activity
GO:0046872	metal ion binding

Biological Process

GO:0006874	cellular calcium ion homeostasis
GO:0019853	L-ascorbic acid biosynthetic process
GO:0032781	positive regulation of ATPase activity
GO:0050848	regulation of calcium-mediated signaling

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR005511 Senescence marker protein-30 (SMP-30)
IPR008367 Regucalcin
IPR013658 SMP-30/Gluconolactonase/LRE-like region

PFAM

PF08450

PRINTS

PR01790
PR01791

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9TTJ5

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

280910

UniGene

Bt.502

RefSeq

NP_776382

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AB035446 BC103461

GenPept

AAI03462 BAA88080