InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TRPC6

Summary

InnateDB Protein

IDBP-68845.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRPC6

Protein Name

transient receptor potential cation channel, subfamily C, member 6

Synonyms

FSGS2; TRP6;

Species

Homo sapiens

Ensembl Protein

ENSP00000353687

InnateDB Gene

IDBG-68841 (TRPC6)

Protein Structure

UniProt Annotation

Function

Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion.

Subcellular Localization

Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Disease Associations

Focal segmental glomerulosclerosis 2 (FSGS2) [MIM:603965]: A renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and progressive decline in renal function. Renal insufficiency often progresses to end-stage renal disease, a highly morbid state requiring either dialysis therapy or kidney transplantation. {ECO:0000269PubMed:15879175, ECO:0000269PubMed:15924139, ECO:0000269PubMed:21734084}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Expressed primarily in placenta, lung, spleen, ovary and small intestine. Expressed in podocytes and is a component of the glomerular slit diaphragm. {ECO:0000269PubMed:15924139}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005488	binding
GO:0005515	protein binding
GO:0070679	inositol 1,4,5 trisphosphate binding

Biological Process

GO:0006811	ion transport
GO:0006812	cation transport
GO:0007411	axon guidance
GO:0007596	blood coagulation
GO:0030168	platelet activation
GO:0032414	positive regulation of ion transmembrane transporter activity
GO:0034220	ion transmembrane transport
GO:0051928	positive regulation of calcium ion transport
GO:0055085	transmembrane transport
GO:0070588	calcium ion transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR002110 Ankyrin repeat
IPR002153 Transient receptor potential channel, canonical
IPR005462 Transient receptor potential channel, canonical 6
IPR005821 Ion transport domain
IPR013122 Polycystin cation channel, PKD1/PKD2
IPR013555 Transient receptor ion channel domain
IPR016024 Armadillo-type fold
IPR020683 Ankyrin repeat-containing domain

PFAM