Version 5.4
Homo sapiens Gene: TRPC6
Summary
InnateDB Gene IDBG-68841.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRPC6
Gene Name transient receptor potential cation channel, subfamily C, member 6
Synonyms FSGS2; TRP6
Species Homo sapiens
Ensembl Gene ENSG00000137672
Encoded Proteins
IDBP-68843
transient receptor potential cation channel, subfamily C, member 6
IDBP-68845
transient receptor potential cation channel, subfamily C, member 6
IDBP-68847
transient receptor potential cation channel, subfamily C, member 6
IDBP-586971
transient receptor potential cation channel, subfamily C, member 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2). [provided by RefSeq, Mar 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:101451564-101872562
Strand Reverse strand
Band q22.1
Transcripts
ENST00000344327 ENSP00000340913
ENST00000360497 ENSP00000353687
ENST00000348423 ENSP00000343672
ENST00000532133 ENSP00000435574
ENST00000532184
ENST00000527240
ENST00000526713
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005261 cation channel activity
GO:0005262 calcium channel activity
GO:0005488 binding
GO:0005515 protein binding
GO:0015279 store-operated calcium channel activity
GO:0070679 inositol 1,4,5 trisphosphate binding
Biological Process
GO:0006811 ion transport
GO:0006812 cation transport
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007411 axon guidance
GO:0007568 aging
GO:0007596 blood coagulation
GO:0030168 platelet activation
GO:0032414 positive regulation of ion transmembrane transporter activity
GO:0034220 ion transmembrane transport
GO:0051928 positive regulation of calcium ion transport
GO:0055085 transmembrane transport
GO:0070301 cellular response to hydrogen peroxide
GO:0070588 calcium ion transmembrane transport
GO:0071456 cellular response to hypoxia
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0036057 slit diaphragm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031997
View Gene Order
ENSBTAG00000011227
Not yet available
Pathways
NETPATH
REACTOME
REACT_160189
Stimuli-sensing channels pathway
REACT_162
Elevation of cytosolic Ca2+ levels pathway
REACT_23876
Platelet homeostasis pathway
REACT_2202
Effects of PIP2 hydrolysis pathway
REACT_18283
G alpha (q) signalling events pathway
REACT_120966
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_22228
Role of second messengers in netrin-1 signaling pathway
REACT_22237
Netrin-1 signaling pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_111045
Developmental Biology pathway
REACT_23905
Platelet calcium homeostasis pathway
REACT_14797
Signaling by GPCR pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_18266
Axon guidance pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_25300
Ion channel transport pathway
REACT_169333
TRP channels pathway
REACT_604
Hemostasis pathway
KEGG
INOH
PID NCI
nephrin_neph1_pathway
Nephrin/Neph1 signaling in the kidney podocyte
thrombin_par1_pathway
PAR1-mediated thrombin signaling events
endothelinpathway
Endothelins
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.159003 Hs.600819 Hs.622646
RefSeq NM_004621
HUGO
OMIM
CCDS CCDS8311
HPRD 04710
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca