Version 5.4
Bos taurus Protein: RASGRP4
Summary
InnateDB Protein IDBP-688559.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RASGRP4
Protein Name RAS guanyl-releasing protein 4
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000042303
InnateDB Gene IDBG-636608 (RASGRP4)
Protein Structure
UniProt Annotation
Function Functions as a cation- and diacylglycerol (DAG)- regulated nucleotide exchange factor activating Ras through the exchange of bound GDP for GTP. May function in mast cells differentiation (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Recruited to membranes upon activation by DAG. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005509 calcium ion binding
GO:0046872 metal ion binding
Biological Process
GO:0007264 small GTPase mediated signal transduction
GO:0008283 cell proliferation
GO:0009991 response to extracellular stimulus
GO:0016049 cell growth
GO:0030154 cell differentiation
GO:0032320 positive regulation of Ras GTPase activity
GO:0035556 intracellular signal transduction
GO:0043547 positive regulation of GTPase activity
GO:0046579 positive regulation of Ras protein signal transduction
GO:0051056 regulation of small GTPase mediated signal transduction
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal
IPR001895 Ras guanine-nucleotide exchange factors catalytic domain
IPR002048 EF-hand domain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
IPR020454 Diacylglycerol/phorbol-ester binding
PFAM PF00618
PF00617
PF00036
PF13202
PF13405
PF00130
PRINTS PR00008
PIRSF
SMART SM00229
SM00147
SM00054
SM00109
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q1LZ97
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 529375
UniGene Bt.32575
RefSeq NP_001030456
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC116130 BT021783
GenPept AAI16131 AAX46630

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca