InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: RASGRP4

Summary

InnateDB Gene

IDBG-636608.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RASGRP4

Gene Name

RAS guanyl-releasing protein 4

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000006998

Encoded Proteins

IDBP-688559

RAS guanyl-releasing protein 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000171777:
The protein encoded by this gene is a member of the Ras guanyl nucleotide-releasing protein (RasGRP) family of Ras guanine nucleotide exchange factors. It contains a Ras exchange motif, a diacylglycerol-binding domain, and two calcium-binding EF hands. This protein was shown to activate H-Ras in a cation-dependent manner in vitro. Expression of this protein in myeloid cell lines was found to be correlated with elevated level of activated RAS protein, and the RAS activation can be greatly enhanced by phorbol ester treatment, which suggested a role of this protein in diacylglycerol regulated cell signaling pathways. Studies of a mast cell leukemia cell line expressing substantial amounts of abnormal transcripts of this gene indicated that this gene may play an important role in the final stages of mast cell development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:48481124-48494788

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000044847

ENSBTAP00000042303

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005088	Ras guanyl-nucleotide exchange factor activity
GO:0005509	calcium ion binding
GO:0046872	metal ion binding

Biological Process

GO:0007264	small GTPase mediated signal transduction
GO:0008283	cell proliferation
GO:0009991	response to extracellular stimulus
GO:0016049	cell growth
GO:0030154	cell differentiation
GO:0032320	positive regulation of Ras GTPase activity
GO:0035556	intracellular signal transduction
GO:0043547	positive regulation of GTPase activity
GO:0046579	positive regulation of Ras protein signal transduction
GO:0051056	regulation of small GTPase mediated signal transduction

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0016020	membrane

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000171777

View Gene Order

ENSMUSG00000030589

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_163994

FCERI mediated NF-kB activation pathway

REACT_6802

Innate Immune System pathway

REACT_163936

Fc epsilon receptor (FCERI) signaling pathway

REACT_6900

Immune System pathway

KEGG

hsa04010

MAPK signaling pathway pathway

mmu04010

MAPK signaling pathway pathway

INOH

PID NCI

ras_pathway

Regulation of Ras family activation

Cross-References

SwissProt

Q1LZ97

TrEMBL

UniProt Splice Variant

Entrez Gene

529375

UniGene

Bt.32575

RefSeq

NM_001035379 XM_005218966

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC116130 BT021783

GenPept

AAI16131 AAX46630

RNA Seq Atlas

529375