InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: UBA1

Summary

InnateDB Protein

IDBP-688587.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UBA1

Protein Name

Ubiquitin-like modifier-activating enzyme 1

Synonyms

UBE1; UBE1X;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000022299

InnateDB Gene

IDBG-636622 (UBA1)

Protein Structure

UniProt Annotation

Function

Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin- E1 thioester and free AMP.

Subcellular Localization

Cytoplasm {ECO:0000250}. Mitochondrion {ECO:0000250}. Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 72 interaction(s) predicted by orthology.

Predicted by orthology
Total	72 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003824	catalytic activity
GO:0004839	ubiquitin activating enzyme activity
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008641	small protein activating enzyme activity
GO:0016874	ligase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006464	cellular protein modification process
GO:0006974	cellular response to DNA damage stimulus
GO:0016567	protein ubiquitination
GO:0019941	modification-dependent protein catabolic process

Cellular Component

GO:0000792	heterochromatin
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005765	lysosomal membrane
GO:0005829	cytosol
GO:0010008	endosome membrane
GO:0030057	desmosome
GO:0030867	rough endoplasmic reticulum membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000011 Ubiquitin/SUMO-activating enzyme E1
IPR000127 Ubiquitin-activating enzyme repeat
IPR000594 UBA/THIF-type NAD/FAD binding fold
IPR018075 Ubiquitin-activating enzyme, E1
IPR018965 Ubiquitin-activating enzyme e1, C-terminal
IPR019572 Ubiquitin-activating enzyme

PFAM

PF02134
PF00899
PF09358
PF10585

PRINTS

PR01849

PIRSF

SMART

SM00985

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

A3KMV5

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

282869

UniGene

Bt.48363

RefSeq

NP_001095947

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC133293

GenPept

AAI33294