InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: UBA1

Summary

InnateDB Gene

IDBG-636622.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UBA1

Gene Name

Ubiquitin-like modifier-activating enzyme 1

Synonyms

UBE1; UBE1X

Species

Bos taurus

Ensembl Gene

ENSBTAG00000016764

Encoded Proteins

IDBP-688587

Ubiquitin-like modifier-activating enzyme 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000130985:
The protein encoded by this gene catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation. This gene complements an X-linked mouse temperature-sensitive defect in DNA synthesis, and thus may function in DNA repair. It is part of a gene cluster on chromosome Xp11.23. Alternatively spliced transcript variants that encode the same protein have been described. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:90831727-90850346

Strand

Forward strand

Band

Transcripts

ENSBTAT00000022299

ENSBTAP00000022299

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 72 interaction(s) predicted by orthology.

Predicted by orthology
Total	72 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003824	catalytic activity
GO:0004839	ubiquitin activating enzyme activity
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008641	small protein activating enzyme activity
GO:0016874	ligase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006464	cellular protein modification process
GO:0006974	cellular response to DNA damage stimulus
GO:0016567	protein ubiquitination
GO:0019941	modification-dependent protein catabolic process

Cellular Component

GO:0000792	heterochromatin
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005765	lysosomal membrane
GO:0005829	cytosol
GO:0010008	endosome membrane
GO:0030057	desmosome
GO:0030867	rough endoplasmic reticulum membrane
GO:0070062	extracellular vesicular exosome