Version 5.4
Homo sapiens Protein: ACSS2
Summary
InnateDB Protein IDBP-68860.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ACSS2
Protein Name acyl-CoA synthetase short-chain family member 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000353804
InnateDB Gene IDBG-68854 (ACSS2)
Protein Structure
UniProt Annotation
Function Activates acetate so that it can be used for lipid synthesis or for energy generation.
Subcellular Localization Cytoplasm.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 2 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0003987 acetate-CoA ligase activity
GO:0005524 ATP binding
GO:0016208 AMP binding
Biological Process
GO:0006069 ethanol oxidation
GO:0006805 xenobiotic metabolic process
GO:0008152 metabolic process
GO:0008610 lipid biosynthetic process
GO:0019427 acetyl-CoA biosynthetic process from acetate
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0043231 intracellular membrane-bounded organelle
Protein Structure and Domains
PDB ID
InterPro IPR000873 AMP-dependent synthetase/ligase
IPR011904 Acetate-CoA ligase
PFAM PF00501
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NR19
PhosphoSite PhosphoSite-Q9NR19
TrEMBL Q96FY7
UniProt Splice Variant
Entrez Gene 55902
UniGene Hs.517034
RefSeq NP_061147
HUGO HGNC:15814
OMIM 605832
CCDS CCDS13243
HPRD
IMGT
EMBL AF263614 AK092281 AK098026 AL049709 AL133324 BC010141 BC012172 BC073846 BC098422 CH471077
GenPept AAF75064 AAH10141 AAH12172 AAH73846 AAH98422 BAC03849 BAG53564 CAI19311 CAI19312 CAI19725 CAI19726 EAW76248

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca