Version 5.4
Homo sapiens Gene: ACSS2
Summary
InnateDB Gene IDBG-68854.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ACSS2
Gene Name acyl-CoA synthetase short-chain family member 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000131069
Encoded Proteins
IDBP-68858
acyl-CoA synthetase short-chain family member 2
IDBP-68860
acyl-CoA synthetase short-chain family member 2
IDBP-479979
acyl-CoA synthetase short-chain family member 2
IDBP-475873
acyl-CoA synthetase short-chain family member 2
IDBP-479240
acyl-CoA synthetase short-chain family member 2
IDBP-479065
acyl-CoA synthetase short-chain family member 2
IDBP-479156
acyl-CoA synthetase short-chain family member 2
IDBP-473583
acyl-CoA synthetase short-chain family member 2
IDBP-477193
acyl-CoA synthetase short-chain family member 2
IDBP-483084
acyl-CoA synthetase short-chain family member 2
IDBP-481537
acyl-CoA synthetase short-chain family member 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a cytosolic enzyme that catalyzes the activation of acetate for use in lipid synthesis and energy generation. The protein acts as a monomer and produces acetyl-CoA from acetate in a reaction that requires ATP. Expression of this gene is regulated by sterol regulatory element-binding proteins, transcription factors that activate genes required for the synthesis of cholesterol and unsaturated fatty acids. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:34872146-34927962
Strand Forward strand
Band q11.22
Transcripts
ENST00000253382 ENSP00000253382
ENST00000360596 ENSP00000353804
ENST00000490046
ENST00000481971
ENST00000497927
ENST00000488172 ENSP00000417783
ENST00000481284 ENSP00000418152
ENST00000475459 ENSP00000420105
ENST00000461051
ENST00000484354 ENSP00000419167
ENST00000480274 ENSP00000418608
ENST00000477932 ENSP00000418362
ENST00000493805 ENSP00000418812
ENST00000473172 ENSP00000419925
ENST00000480978 ENSP00000420351
ENST00000467019
ENST00000476922
ENST00000464399
ENST00000468550
ENST00000493250
ENST00000491533
ENST00000490464
ENST00000470315
ENST00000494727
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 2 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0003987 acetate-CoA ligase activity
GO:0005524 ATP binding
GO:0016208 AMP binding
Biological Process
GO:0006069 ethanol oxidation
GO:0006085 acetyl-CoA biosynthetic process
GO:0006805 xenobiotic metabolic process
GO:0008152 metabolic process
GO:0008610 lipid biosynthetic process
GO:0019413 acetate biosynthetic process
GO:0019427 acetyl-CoA biosynthetic process from acetate
GO:0019542 propionate biosynthetic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027605
View Gene Order
ENSBTAG00000013303
Not yet available
Pathways
NETPATH
REACTOME
REACT_34
Ethanol oxidation pathway
REACT_111217
Metabolism pathway
REACT_13433
Biological oxidations pathway
REACT_13705
Phase 1 - Functionalization of compounds pathway
KEGG
hsa00010
Glycolysis / Gluconeogenesis pathway
hsa00620
Pyruvate metabolism pathway
hsa00640
Propanoate metabolism pathway
INOH
INOH website
Propanoate metabolism pathway
INOH website
Pyruvate metabolism pathway
PID NCI
hdac_classiii_pathway
Signaling events mediated by HDAC Class III
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.517034
RefSeq NM_001076552 NM_001242393 NM_018677
HUGO
OMIM
CCDS CCDS13243 CCDS42868
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca