Version 5.4
Bos taurus Protein: RIPK1
Summary
InnateDB Protein IDBP-688629.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RIPK1
Protein Name receptor-interacting serine/threonine-protein kinase 1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000008367
InnateDB Gene IDBG-636679 (RIPK1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 119 interaction(s) predicted by orthology.
Predicted by orthology
Total 119 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005123 death receptor binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0031625 ubiquitin protein ligase binding
GO:0032403 protein complex binding
GO:0042802 identical protein binding
GO:0070513 death domain binding
Biological Process
GO:0001934 positive regulation of protein phosphorylation
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0016310 phosphorylation
GO:0032757 positive regulation of interleukin-8 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0034612 response to tumor necrosis factor
GO:0036289 peptidyl-serine autophosphorylation
GO:0042327 positive regulation of phosphorylation
GO:0043065 positive regulation of apoptotic process
GO:0043068 positive regulation of programmed cell death
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043410 positive regulation of MAPK cascade
GO:0044257 cellular protein catabolic process
GO:0045651 positive regulation of macrophage differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046330 positive regulation of JNK cascade
GO:0046777 protein autophosphorylation
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051260 protein homooligomerization
GO:0051291 protein heterooligomerization
GO:0051347 positive regulation of transferase activity
GO:0060545 positive regulation of necroptotic process
GO:0070231 T cell apoptotic process
GO:0070266 necroptotic process
GO:0070926 regulation of ATP:ADP antiporter activity
GO:0071356 cellular response to tumor necrosis factor
GO:0071363 cellular response to growth factor stimulus
GO:0097191 extrinsic apoptotic signaling pathway
GO:0097343 ripoptosome assembly
GO:0097527 necroptotic signaling pathway
GO:1901026 ripoptosome assembly involved in necroptotic process
GO:1990000 amyloid fibril formation
GO:2000377 regulation of reactive oxygen species metabolic process
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
Cellular Component
GO:0005739 mitochondrion
GO:0031264 death-inducing signaling complex
GO:0043235 receptor complex
GO:0097342 ripoptosome
Protein Structure and Domains
PDB ID
InterPro IPR000488 Death domain
IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR011029 Death-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain
PFAM PF00531
PF00069
PF07714
PRINTS PR00109
PIRSF
SMART SM00005
SM00220
SM00219
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q3SZK6
UniProt Splice Variant
Entrez Gene 504727
UniGene Bt.6302
RefSeq NP_001030184
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC102809 DAAA02055899
GenPept AAI02810

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca