InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: USP7

Summary

InnateDB Protein

IDBP-688738.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

USP7

Protein Name

Ubiquitin carboxyl-terminal hydrolase

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000007177

InnateDB Gene

IDBG-636643 (USP7)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 165 interaction(s) predicted by orthology.

Predicted by orthology
Total	165 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002039	p53 binding
GO:0004197	cysteine-type endopeptidase activity
GO:0004221	ubiquitin thiolesterase activity
GO:0004843	ubiquitin-specific protease activity
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0008134	transcription factor binding
GO:0008233	peptidase activity
GO:0008234	cysteine-type peptidase activity
GO:0016787	hydrolase activity
GO:0031625	ubiquitin protein ligase binding
GO:0036459	ubiquitinyl hydrolase activity

Biological Process

GO:0006283	transcription-coupled nucleotide-excision repair
GO:0006508	proteolysis
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0010216	maintenance of DNA methylation
GO:0016579	protein deubiquitination
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0051090	regulation of sequence-specific DNA binding transcription factor activity

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase
IPR002083 MATH
IPR008974 TRAF-like
IPR024729 ICP0-binding domain of Ubiquitin-specific protease 7
IPR028889 Ubiquitin carboxyl-terminal hydrolase-like domain

PFAM

PF00443
PF00917
PF12436

PRINTS

PIRSF

SMART

SM00061

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite