Version 5.4
Bos taurus Gene: USP7
Summary
InnateDB Gene IDBG-636643.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol USP7
Gene Name Ubiquitin carboxyl-terminal hydrolase
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000005455
Encoded Proteins
IDBP-688738
Ubiquitin carboxyl-terminal hydrolase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 18952891
[Homo sapiens] Cytoplasmic USP7 binds to and deubiquitinates TRAF6 and IKBKG, thus terminating TLR-mediated NF-kappaB and JNK activation
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000187555:
Gene Information
Type Protein coding
Genomic Location Chromosome 25:7769457-7796941
Strand Reverse strand
Band
Transcripts
ENSBTAT00000007177 ENSBTAP00000007177
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 165 interaction(s) predicted by orthology.
Predicted by orthology
Total 165 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002039 p53 binding
GO:0004197 cysteine-type endopeptidase activity
GO:0004221 ubiquitin thiolesterase activity
GO:0004843 ubiquitin-specific protease activity
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
GO:0008134 transcription factor binding
GO:0008233 peptidase activity
GO:0008234 cysteine-type peptidase activity
GO:0016787 hydrolase activity
GO:0031625 ubiquitin protein ligase binding
GO:0036459 ubiquitinyl hydrolase activity
Biological Process
GO:0006283 transcription-coupled nucleotide-excision repair
GO:0006508 proteolysis
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0010216 maintenance of DNA methylation
GO:0016579 protein deubiquitination
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0051090 regulation of sequence-specific DNA binding transcription factor activity
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000187555
View Gene Order
ENSMUSG00000022710
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
foxopathway
FoxO family signaling
p53regulationpathway
p53 pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.11902
RefSeq XM_002697958 XM_002703063 XM_005196911 XM_005224667
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca