InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: APAF1

Summary

InnateDB Protein

IDBP-688807.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

APAF1

Protein Name

apoptotic peptidase activating factor 1

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000028867

InnateDB Gene

IDBG-636787 (APAF1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0042802	identical protein binding
GO:0043531	ADP binding

Biological Process

GO:0001843	neural tube closure
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006952	defense response
GO:0007275	multicellular organismal development
GO:0007420	brain development
GO:0008635	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0030900	forebrain development
GO:0042981	regulation of apoptotic process
GO:0051402	neuron apoptotic process
GO:1902510	regulation of apoptotic DNA fragmentation
GO:2001235	positive regulation of apoptotic signaling pathway

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005829	cytosol
GO:0043293	apoptosome
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001315 CARD domain
IPR001680 WD40 repeat
IPR002182 NB-ARC
IPR011029 Death-like domain
IPR017251 Apoptotic protease-activating factor 1
IPR017986 WD40-repeat-containing domain
IPR020472 G-protein beta WD-40 repeat
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00619
PF00400
PF00931

PRINTS

PR00320

PIRSF

PIRSF037646

SMART

SM00114
SM00320

TIGRFAMs

Post-translational Modifications

Modification

Cross-References