Bos taurus Gene: APAF1 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-636787.3 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | APAF1 | ||||||||||||||||||||||
Gene Name | apoptotic protease-activating factor 1 | ||||||||||||||||||||||
Synonyms | |||||||||||||||||||||||
Species | Bos taurus | ||||||||||||||||||||||
Ensembl Gene | ENSBTAG00000021661 | ||||||||||||||||||||||
Encoded Proteins |
apoptotic peptidase activating factor 1
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000120868:
This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 5:63125171-63207075 | ||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||
Band | |||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
NETPATH |
TNFalpha pathway
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REACTOME |
Activation of caspases through apoptosome-mediated cleavage pathway
Formation of apoptosome pathway
Apoptosis pathway
Apoptotic factor-mediated response pathway
Cytochrome c-mediated apoptotic response pathway
Intrinsic Pathway for Apoptosis pathway
Apoptosis pathway
Activation of caspases through apoptosome-mediated cleavage pathway
Cytochrome c-mediated apoptotic response pathway
Formation of apoptosome pathway
Apoptotic factor-mediated response pathway
Intrinsic Pathway for Apoptosis pathway
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KEGG |
Apoptosis pathway
Alzheimer's disease pathway
Small cell lung cancer pathway
p53 signaling pathway pathway
Amyotrophic lateral sclerosis (ALS) pathway
Parkinson's disease pathway
Huntington's disease pathway
p53 signaling pathway pathway
Alzheimer's disease pathway
Small cell lung cancer pathway
Apoptosis pathway
Parkinson's disease pathway
Amyotrophic lateral sclerosis (ALS) pathway
Huntington's disease pathway
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INOH |
TNFR1 signaling pathway pathway
Fas signaling pathway pathway
TNFR1 signaling pathway pathway
Fas signaling pathway pathway
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PID NCI |
Caspase Cascade in Apoptosis
Direct p53 effectors
p75(NTR)-mediated signaling
E2F transcription factor network
HIV-1 Nef: Negative effector of Fas and TNF-alpha
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Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | F1MUW4 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 537782 | ||||||||||||||||||||||
UniGene | Bt.27298 | ||||||||||||||||||||||
RefSeq | NM_001191507 XM_005206645 XM_005206646 XM_005206647 | ||||||||||||||||||||||
HUGO | HGNC:576 | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | |||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | DAAA02013645 DAAA02013646 DAAA02013647 | ||||||||||||||||||||||
GenPept | |||||||||||||||||||||||
RNA Seq Atlas | 537782 | ||||||||||||||||||||||