InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: BT.25870

Summary

InnateDB Protein

IDBP-688843.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.25870

Protein Name

histone-lysine N-methyltransferase SUV39H1

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000006178

InnateDB Gene

IDBG-636872 (BT.25870)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 50 interaction(s) predicted by orthology.

Predicted by orthology
Total	50 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000976	transcription regulatory region sequence-specific DNA binding
GO:0005515	protein binding
GO:0008168	methyltransferase activity
GO:0008270	zinc ion binding
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity
GO:0016740	transferase activity
GO:0018024	histone-lysine N-methyltransferase activity
GO:0042054	histone methyltransferase activity
GO:0046974	histone methyltransferase activity (H3-K9 specific)
GO:0047485	protein N-terminus binding

Biological Process

GO:0000183	chromatin silencing at rDNA
GO:0032259	methylation
GO:0034968	histone lysine methylation
GO:0036123	histone H3-K9 dimethylation
GO:0036124	histone H3-K9 trimethylation
GO:0042754	negative regulation of circadian rhythm
GO:0045892	negative regulation of transcription, DNA-templated
GO:0051567	histone H3-K9 methylation

Cellular Component

GO:0000792	heterochromatin
GO:0005634	nucleus
GO:0005677	chromatin silencing complex
GO:0005694	chromosome
GO:0033553	rDNA heterochromatin

Protein Structure and Domains

PDB ID

InterPro

IPR000953 Chromo domain/shadow
IPR001214 SET domain
IPR003606 Pre-SET zinc-binding sub-group
IPR003616 Post-SET domain
IPR007728 Pre-SET domain
IPR011381 Histone H3-K9 methyltransferase
IPR016197 Chromo domain-like
IPR023780 Chromo domain

PFAM

PF00856
PF05033
PF00385

PRINTS

PIRSF

PIRSF009343

SMART

SM00298
SM00317
SM00468
SM00508

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt