InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.25870

Summary

InnateDB Gene

IDBG-636872.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.25870

Gene Name

histone-lysine N-methyltransferase SUV39H1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000004706

Encoded Proteins

IDBP-688843

histone-lysine N-methyltransferase SUV39H1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000101945:
This gene is a member of the suppressor of variegation 3-9 homolog family and encodes a protein with a chromodomain and a C-terminal SET domain. This nuclear protein moves to the centromeres during mitosis and functions as a histone methyltransferase, methylating Lys-9 of histone H3. Overall, it plays a vital role in heterochromatin organization, chromosome segregation, and mitotic progression. [provided by RefSeq, Jul 2008]
This gene encodes an evolutionarily-conserved protein containing an N-terminal chromodomain and a C-terminal SET domain. The encoded protein is a histone methyltransferase that trimethylates lysine 9 of histone H3, which results in transcriptional gene silencing. Loss of function of this gene disrupts heterochromatin formation and may cause chromosome instability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:91856090-91868994

Strand

Forward strand

Band

Transcripts

ENSBTAT00000006178

ENSBTAP00000006178

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 50 interaction(s) predicted by orthology.

Predicted by orthology
Total	50 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000976	transcription regulatory region sequence-specific DNA binding
GO:0005515	protein binding
GO:0008168	methyltransferase activity
GO:0008270	zinc ion binding
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity
GO:0016740	transferase activity
GO:0018024	histone-lysine N-methyltransferase activity
GO:0042054	histone methyltransferase activity
GO:0046974	histone methyltransferase activity (H3-K9 specific)
GO:0047485	protein N-terminus binding

Biological Process

GO:0000183	chromatin silencing at rDNA
GO:0032259	methylation
GO:0034968	histone lysine methylation
GO:0036123	histone H3-K9 dimethylation
GO:0036124	histone H3-K9 trimethylation
GO:0042754	negative regulation of circadian rhythm
GO:0045892	negative regulation of transcription, DNA-templated
GO:0051567	histone H3-K9 methylation