Version 5.4
Homo sapiens Protein: CRYGS
Summary
InnateDB Protein IDBP-68885.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CRYGS
Protein Name crystallin, gamma S
Synonyms CRYG8; CTRCT20;
Species Homo sapiens
Ensembl Protein ENSP00000312099
InnateDB Gene IDBG-245537 (CRYGS)
Protein Structure
UniProt Annotation
Function Crystallins are the dominant structural components of the vertebrate eye lens.
Subcellular Localization
Disease Associations Cataract 20, multiple types (CTRCT20) [MIM:116100]: An opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an opacity, the greater the impact on visual function. CTRCT20 includes progressive polymorphic anterior, posterior, or peripheral cortical. {ECO:0000269PubMed:16141006}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Protein Structure and Domains
PDB ID
InterPro IPR001064 Beta/gamma crystallin
IPR011024 Gamma-crystallin-related
PFAM PF00030
PRINTS PR01367
PIRSF
SMART SM00247
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P22914
PhosphoSite PhosphoSite-P22914
TrEMBL Q9UFA7
UniProt Splice Variant
Entrez Gene 1427
UniGene
RefSeq NP_060011
HUGO HGNC:2417
OMIM 123730
CCDS CCDS3275
HPRD 00439
IMGT
EMBL AF161703 AF242197 AF242198 AK314172 AL133079 BC069478 BC070241 CH471052 L36869
GenPept AAA92870 AAD45901 AAF72490 AAH69478 AAH70241 BAG36855 CAB61399 EAW78194 EAW78195 EAW78196

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca