InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: BCHE

Summary

InnateDB Protein

IDBP-688860.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BCHE

Protein Name

Cholinesterase

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000014794

InnateDB Gene

IDBG-636889 (BCHE)

Protein Structure

UniProt Annotation

Function

Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted {ECO:0000250}.

Disease Associations

Tissue Specificity

Present in most cells except erythrocytes.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003990	acetylcholinesterase activity
GO:0004104	cholinesterase activity
GO:0016787	hydrolase activity
GO:0042802	identical protein binding

Biological Process

GO:0007271	synaptic transmission, cholinergic
GO:0008152	metabolic process
GO:0019695	choline metabolic process

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005641	nuclear envelope lumen
GO:0005783	endoplasmic reticulum
GO:0005788	endoplasmic reticulum lumen
GO:0072562	blood microparticle

Protein Structure and Domains

PDB ID

InterPro

IPR000997 Cholinesterase
IPR002018 Carboxylesterase, type B
IPR013094 Alpha/beta hydrolase fold-3
IPR014788 Acetylcholinesterase, tetramerisation domain
IPR029058 Alpha/Beta hydrolase fold

PFAM

PF00135
PF07859
PF08674

PRINTS

PR00878

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P32749