InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BCHE

Summary

InnateDB Gene

IDBG-636889.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BCHE

Gene Name

Cholinesterase

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000011139

Encoded Proteins

IDBP-688860

Cholinesterase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000114200:
Mutant alleles at the BCHE locus are responsible for suxamethonium sensitivity. Homozygous persons sustain prolonged apnea after administration of the muscle relaxant suxamethonium in connection with surgical anesthesia. The activity of pseudocholinesterase in the serum is low and its substrate behavior is atypical. In the absence of the relaxant, the homozygote is at no known disadvantage. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:102337857-102409795

Strand

Forward strand

Band

Transcripts

ENSBTAT00000014794

ENSBTAP00000014794

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003990	acetylcholinesterase activity
GO:0004104	cholinesterase activity
GO:0016787	hydrolase activity
GO:0042802	identical protein binding

Biological Process

GO:0007271	synaptic transmission, cholinergic
GO:0008152	metabolic process
GO:0019695	choline metabolic process

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005641	nuclear envelope lumen
GO:0005783	endoplasmic reticulum
GO:0005788	endoplasmic reticulum lumen
GO:0072562	blood microparticle