InnateDB Protein
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IDBP-68895.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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LILRB4
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Protein Name
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leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
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Synonyms
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CD85K; ILT-3; ILT3; LIR-5; LIR5;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000270452
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InnateDB Gene
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IDBG-68893 (LILRB4)
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Protein Structure
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Function |
Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance, e.g. towards transplants. Interferes with TNFRSF5- signaling and NF-kappa-B up-regulation. Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions. {ECO:0000269PubMed:11875462, ECO:0000269PubMed:9151699}.
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Subcellular Localization |
Cell membrane {ECO:0000269PubMed:9151699}; Single-pass type I membrane protein {ECO:0000269PubMed:9151699}. Note=Ligand binding leads to internalization and translocation to an antigen-processing compartment.
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Disease Associations |
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Tissue Specificity |
Detected in monocytes, macrophages, dendritic cells, lung, natural killer cells and B-cells. {ECO:0000269PubMed:9151699, ECO:0000269PubMed:9278324, ECO:0000269PubMed:9548455}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
3
[view]
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Protein-Protein |
3
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8NHJ6
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PhosphoSite |
PhosphoSite-Q8NHJ6
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
11006
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UniGene |
Hs.67846
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RefSeq |
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HUGO |
HGNC:6608
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OMIM |
604821
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CCDS |
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HPRD |
11996
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IMGT |
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EMBL |
AC009892
AC011515
AF025532
AF189768
AF283988
BC026309
CR542048
CR609786
U91925
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GenPept |
AAB68665
AAB87666
AAG02024
AAH26309
AAL36992
CAG46845
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