Version 5.4
Bos taurus Protein: SEMA4D
Summary
InnateDB Protein IDBP-689029.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SEMA4D
Protein Name sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000002525
InnateDB Gene IDBG-637043 (SEMA4D)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0004888 transmembrane signaling receptor activity
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0030215 semaphorin receptor binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001934 positive regulation of protein phosphorylation
GO:0007162 negative regulation of cell adhesion
GO:0007275 multicellular organismal development
GO:0008360 regulation of cell shape
GO:0010693 negative regulation of alkaline phosphatase activity
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0030335 positive regulation of cell migration
GO:0031344 regulation of cell projection organization
GO:0032321 positive regulation of Rho GTPase activity
GO:0043931 ossification involved in bone maturation
GO:0045668 negative regulation of osteoblast differentiation
GO:0048672 positive regulation of collateral sprouting
GO:0048814 regulation of dendrite morphogenesis
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation
GO:0050772 positive regulation of axonogenesis
GO:0070486 leukocyte aggregation
GO:0071526 semaphorin-plexin signaling pathway
GO:1900220 semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis
Cellular Component
GO:0005615 extracellular space
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR001627 Sema domain
IPR002165 Plexin
IPR007110 Immunoglobulin-like domain
IPR016201 Plexin-like fold
PFAM PF01403
PF01437
PRINTS
PIRSF
SMART SM00630
SM00423
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL A5D7C8
UniProt Splice Variant
Entrez Gene 785942
UniGene Bt.103001
RefSeq NP_001091629
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC140509 DAAA02024214 DAAA02024215
GenPept AAI40510

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca