Version 5.4
Bos taurus Protein: IL2RA
Summary
InnateDB Protein IDBP-689049.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL2RA
Protein Name interleukin-2 receptor subunit alpha precursor
Synonyms CD25;
Species Bos taurus
Ensembl Protein ENSBTAP00000027834
InnateDB Gene IDBG-637067 (IL2RA)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004911 interleukin-2 receptor activity
GO:0005515 protein binding
GO:0019976 interleukin-2 binding
Biological Process
GO:0006924 activation-induced cell death of T cells
GO:0007219 Notch signaling pathway
GO:0042104 positive regulation of activated T cell proliferation
GO:0042130 negative regulation of T cell proliferation
GO:0043029 T cell homeostasis
GO:0046013 regulation of T cell homeostatic proliferation
GO:0050672 negative regulation of lymphocyte proliferation
GO:0050728 negative regulation of inflammatory response
Cellular Component
GO:0009897 external side of plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR000436 Sushi/SCR/CCP
PFAM PF00084
PRINTS
PIRSF
SMART SM00032
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL A2VE30
UniProt Splice Variant
Entrez Gene 281861
UniGene Bt.3941
RefSeq NP_776783
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC133546 DAAA02035345
GenPept AAI33547

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca