InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: PRKG1

Summary

InnateDB Protein

IDBP-689096.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRKG1

Protein Name

cGMP-dependent protein kinase 1

Synonyms

cGK 1; CGKI; cGKI-beta;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000030518

InnateDB Gene

IDBG-637097 (PRKG1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004692	cGMP-dependent protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005246	calcium channel regulator activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0030553	cGMP binding

Biological Process

GO:0001764	neuron migration
GO:0006468	protein phosphorylation
GO:0007165	signal transduction
GO:0016310	phosphorylation
GO:0016358	dendrite development
GO:0019934	cGMP-mediated signaling
GO:0030900	forebrain development
GO:0043087	regulation of GTPase activity
GO:0045986	negative regulation of smooth muscle contraction
GO:0060087	relaxation of vascular smooth muscle
GO:0090331	negative regulation of platelet aggregation

Cellular Component

GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000595 Cyclic nucleotide-binding domain
IPR000719 Protein kinase domain
IPR000961 AGC-kinase, C-terminal
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR002373 cAMP/cGMP-dependent protein kinase
IPR002374 cGMP-dependent kinase
IPR011009 Protein kinase-like domain
IPR016232 cGMP-dependent protein kinase
IPR018490 Cyclic nucleotide-binding-like
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00027
PF00069
PF07714

PRINTS

PR00109
PR00103
PR00104

PIRSF

PIRSF000559

SMART

SM00100
SM00133
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References