Version 5.4
Bos taurus Protein: S1PR3
Summary
InnateDB Protein IDBP-689104.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol S1PR3
Protein Name sphingosine 1-phosphate receptor 3
Synonyms EDG3;
Species Bos taurus
Ensembl Protein ENSBTAP00000015111
InnateDB Gene IDBG-637121 (S1PR3)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0005178 integrin binding
GO:0038036 sphingosine-1-phosphate receptor activity
Biological Process
GO:0001816 cytokine production
GO:0003376 sphingosine-1-phosphate signaling pathway
GO:0006954 inflammatory response
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0032651 regulation of interleukin-1 beta production
GO:1903141 negative regulation of establishment of endothelial barrier
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000987 EDG-1 sphingosine 1-phosphate receptor
IPR002230 Cannabinoid receptor family
IPR004061 Sphingosine 1-phosphate receptor
IPR004062 EDG-3 sphingosine 1-phosphate receptor
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
PFAM PF00001
PF10320
PRINTS PR00237
PR00642
PR00362
PR01523
PR01524
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL A6QR17
UniProt Splice Variant
Entrez Gene 539123
UniGene Bt.54465
RefSeq NP_001094656
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC150076 DAAA02024222
GenPept AAI50077

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca