Version 5.4
Bos taurus Protein: HSD17B10
Summary
InnateDB Protein IDBP-689422.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HSD17B10
Protein Name 3-hydroxyacyl-CoA dehydrogenase type-2
Synonyms HADH2;
Species Bos taurus
Ensembl Protein ENSBTAP00000023642
InnateDB Gene IDBG-637418 (HSD17B10)
Protein Structure
UniProt Annotation
Function Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/TRMT10C, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5'-ends. Catalyzes the beta-oxidation at position 17 of androgens and estrogens and has 3-alpha-hydroxysteroid dehydrogenase activity with androsterone. Catalyzes the third step in the beta-oxidation of fatty acids. Carries out oxidative conversions of 7-alpha-OH and 7-beta-OH bile acids. Also exhibits 20-beta-OH and 21-OH dehydrogenase activities with C21 steroids (By similarity). {ECO:0000250}.
Subcellular Localization Mitochondrion {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.
Predicted by orthology
Total 20 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
GO:0030283 testosterone dehydrogenase [NAD(P)] activity
GO:0044822 poly(A) RNA binding
GO:0047015 3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity
Biological Process
GO:0008033 tRNA processing
GO:0008152 metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005783 endoplasmic reticulum
Protein Structure and Domains
PDB ID
InterPro IPR002198 Short-chain dehydrogenase/reductase SDR
IPR002347 Glucose/ribitol dehydrogenase
IPR002424 Alcohol dehydrogenase, insect-type
IPR003560 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase
IPR013968 Polyketide synthase, KR
IPR020842 Polyketide synthase/Fatty acid synthase, KR
PFAM PF00106
PF08659
PRINTS PR00080
PR00081
PR01167
PR01397
PIRSF PIRSF000126
SMART SM00822
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O02691
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 281809
UniGene
RefSeq NP_776759
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AB002156 BC110264
GenPept AAI10265 BAA19510

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca