Version 5.4
Bos taurus Protein: TDG
Summary
InnateDB Protein IDBP-689428.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TDG
Protein Name G/T mismatch-specific thymine DNA glycosylase
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000028828
InnateDB Gene IDBG-637417 (TDG)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.
Predicted by orthology
Total 31 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001104 RNA polymerase II transcription cofactor activity
GO:0003690 double-stranded DNA binding
GO:0005080 protein kinase C binding
GO:0005515 protein binding
GO:0008263 pyrimidine-specific mismatch base pair DNA N-glycosylase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds
GO:0019104 DNA N-glycosylase activity
GO:0030983 mismatched DNA binding
GO:0032183 SUMO binding
GO:0042803 protein homodimerization activity
GO:0043566 structure-specific DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006281 DNA repair
GO:0006284 base-excision repair
GO:0006298 mismatch repair
GO:0006366 transcription from RNA polymerase II promoter
GO:0009790 embryo development
GO:0032091 negative regulation of protein binding
GO:0035562 negative regulation of chromatin binding
GO:0040029 regulation of gene expression, epigenetic
GO:0080111 DNA demethylation
Cellular Component
GO:0005634 nucleus
GO:0005886 plasma membrane
GO:0016605 PML body
Protein Structure and Domains
PDB ID
InterPro IPR003310 Thymine-DNA glycosylase
IPR005122 Uracil-DNA glycosylase-like
PFAM PF03167
PRINTS
PIRSF
SMART SM00986
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL A4IF83
UniProt Splice Variant
Entrez Gene 517825
UniGene Bt.7318
RefSeq NP_001077165
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC134451 DAAA02013719
GenPept AAI34452

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca