Bos taurus Gene: TDG | |||||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||||
InnateDB Gene | IDBG-637417.3 | ||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||
Gene Symbol | TDG | ||||||||||||||||||||||||||
Gene Name | G/T mismatch-specific thymine DNA glycosylase | ||||||||||||||||||||||||||
Synonyms | |||||||||||||||||||||||||||
Species | Bos taurus | ||||||||||||||||||||||||||
Ensembl Gene | ENSBTAG00000021633 | ||||||||||||||||||||||||||
Encoded Proteins |
G/T mismatch-specific thymine DNA glycosylase
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Protein Structure | |||||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000139372:
The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||||
Genomic Location | Chromosome 5:67973222-67994056 | ||||||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||||||
Band | |||||||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||||||
REACTOME |
Displacement of DNA glycosylase by APE1 pathway
Base-free sugar-phosphate removal via the single-nucleotide replacement pathway pathway
Resolution of AP sites via the single-nucleotide replacement pathway pathway
Cleavage of the damaged pyrimidine pathway
Removal of DNA patch containing abasic residue pathway
Resolution of AP sites via the multiple-nucleotide patch replacement pathway pathway
Recognition and association of DNA glycosylase with site containing an affected pyrimidine pathway
Resolution of Abasic Sites (AP sites) pathway
TET1,2,3 and TDG demethylate DNA pathway
Depyrimidination pathway
Epigenetic regulation of gene expression pathway
Base Excision Repair pathway
Base-Excision Repair, AP Site Formation pathway
Gene Expression pathway
DNA Repair pathway
Base-free sugar-phosphate removal via the single-nucleotide replacement pathway pathway
Displacement of DNA glycosylase by APE1 pathway
Resolution of AP sites via the single-nucleotide replacement pathway pathway
Base Excision Repair pathway
Base-Excision Repair, AP Site Formation pathway
Resolution of AP sites via the multiple-nucleotide patch replacement pathway pathway
Depyrimidination pathway
DNA Repair pathway
Cleavage of the damaged pyrimidine pathway
Epigenetic regulation of gene expression pathway
TET1,2,3 and TDG demethylate DNA pathway
Removal of DNA patch containing abasic residue pathway
Gene Expression pathway
Recognition and association of DNA glycosylase with site containing an affected pyrimidine pathway
Resolution of Abasic Sites (AP sites) pathway
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KEGG |
Base excision repair pathway
Base excision repair pathway
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INOH | |||||||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||||||
TrEMBL | A4IF83 | ||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||
Entrez Gene | 517825 | ||||||||||||||||||||||||||
UniGene | Bt.7318 | ||||||||||||||||||||||||||
RefSeq | NM_001083696 | ||||||||||||||||||||||||||
HUGO | |||||||||||||||||||||||||||
OMIM | |||||||||||||||||||||||||||
CCDS | |||||||||||||||||||||||||||
HPRD | |||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||
EMBL | BC134451 DAAA02013719 | ||||||||||||||||||||||||||
GenPept | AAI34452 | ||||||||||||||||||||||||||
RNA Seq Atlas | 517825 | ||||||||||||||||||||||||||