Bos taurus Protein: FKBP1B
Summary
InnateDB Protein IDBP-689484.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FKBP1B
Protein Name Peptidyl-prolyl cis-trans isomerase FKBP1B
Synonyms FKBP12.6;
Species Bos taurus
Ensembl Protein ENSBTAP00000004419
InnateDB Gene IDBG-637475 (FKBP1B)
Protein Structure
UniProt Annotation
Function Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:7520438}. Sarcoplasmic reticulum {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003755 peptidyl-prolyl cis-trans isomerase activity
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0005528 FK506 binding
GO:0016853 isomerase activity
GO:0019855 calcium channel inhibitor activity
GO:0044325 ion channel binding
Biological Process
GO:0000413 protein peptidyl-prolyl isomerization
GO:0002027 regulation of heart rate
GO:0006457 protein folding
GO:0006939 smooth muscle contraction
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0009749 response to glucose
GO:0010459 negative regulation of heart rate
GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0014808 release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0019227 neuronal action potential propagation
GO:0030073 insulin secretion
GO:0032513 negative regulation of protein phosphatase type 2B activity
GO:0042098 T cell proliferation
GO:0051209 release of sequestered calcium ion into cytosol
GO:0051280 negative regulation of release of sequestered calcium ion into cytosol
GO:0051284 positive regulation of sequestering of calcium ion
GO:0051480 cytosolic calcium ion homeostasis
GO:0051775 response to redox state
GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity
GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity
GO:0061077 chaperone-mediated protein folding
GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus
Cellular Component
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0016529 sarcoplasmic reticulum
GO:0030018 Z disc
GO:0033017 sarcoplasmic reticulum membrane
GO:0034704 calcium channel complex
Protein Structure and Domains
PDB ID
InterPro IPR001179 Peptidyl-prolyl cis-trans isomerase, FKBP-type, domain
PFAM PF00254
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P68107
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 785179
UniGene Bt.76948
RefSeq NP_001091627
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC140549
GenPept AAI40550