InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: FKBP1B

Summary

InnateDB Gene

IDBG-637475.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FKBP1B

Gene Name

Peptidyl-prolyl cis-trans isomerase FKBP1B

Synonyms

FKBP12.6

Species

Bos taurus

Ensembl Gene

ENSBTAG00000003409

Encoded Proteins

IDBP-689484

Peptidyl-prolyl cis-trans isomerase FKBP1B

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000119782:
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is highly similar to the FK506-binding protein 1A. Its physiological role is thought to be in excitation-contraction coupling in cardiac muscle. There are two alternatively spliced transcript variants of this gene encoding different isoforms. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:75052326-75063188

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000004419

ENSBTAP00000004419

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003755	peptidyl-prolyl cis-trans isomerase activity
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0005528	FK506 binding
GO:0016853	isomerase activity
GO:0019855	calcium channel inhibitor activity
GO:0044325	ion channel binding

Biological Process

GO:0000413	protein peptidyl-prolyl isomerization
GO:0002027	regulation of heart rate
GO:0006457	protein folding
GO:0006939	smooth muscle contraction
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0009749	response to glucose
GO:0010459	negative regulation of heart rate
GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0010881	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0014808	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0019227	neuronal action potential propagation
GO:0030073	insulin secretion
GO:0032513	negative regulation of protein phosphatase type 2B activity
GO:0042098	T cell proliferation
GO:0051209	release of sequestered calcium ion into cytosol
GO:0051280	negative regulation of release of sequestered calcium ion into cytosol
GO:0051284	positive regulation of sequestering of calcium ion
GO:0051480	cytosolic calcium ion homeostasis
GO:0051775	response to redox state
GO:0060314	regulation of ryanodine-sensitive calcium-release channel activity
GO:0060315	negative regulation of ryanodine-sensitive calcium-release channel activity
GO:0061077	chaperone-mediated protein folding
GO:0061179	negative regulation of insulin secretion involved in cellular response to glucose stimulus

Cellular Component

GO:0005737	cytoplasm
GO:0016020	membrane
GO:0016529	sarcoplasmic reticulum
GO:0030018	Z disc
GO:0033017	sarcoplasmic reticulum membrane
GO:0034704	calcium channel complex