Version 5.4
Homo sapiens Protein: FETUB
Summary
InnateDB Protein IDBP-68970.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FETUB
Protein Name fetuin B
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000265029
InnateDB Gene IDBG-68968 (FETUB)
Protein Structure
UniProt Annotation
Function Protease inhibitor required for egg fertilization. Required to prevent premature zona pellucida hardening before fertilization, probably by inhibiting the protease activity of ASTL, a protease that mediates the cleavage of ZP2 and triggers zona pellucida hardening (By similarity). {ECO:0000250}.
Subcellular Localization Secreted {ECO:0000250}.
Disease Associations
Tissue Specificity Liver and testis.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0004869 cysteine-type endopeptidase inhibitor activity
GO:0008191 metalloendopeptidase inhibitor activity
Biological Process
GO:0007338 single fertilization
GO:0007339 binding of sperm to zona pellucida
GO:0008150 biological_process
GO:0010951 negative regulation of endopeptidase activity
Cellular Component
GO:0005615 extracellular space
Protein Structure and Domains
PDB ID
InterPro IPR000010 Proteinase inhibitor I25, cystatin
PFAM PF00031
PRINTS
PIRSF
SMART SM00043
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UGM5
PhosphoSite PhosphoSite-Q9UGM5
TrEMBL C9JC68
UniProt Splice Variant
Entrez Gene 26998
UniGene Hs.81073
RefSeq NP_055190
HUGO HGNC:3658
OMIM 605954
CCDS CCDS3279
HPRD 09335
IMGT
EMBL AB017551 AC068631 AF534529 AJ242928 AK303859 AK315309 AY373820 BC069670 BC069820 BC074734 BC114616 CH471052
GenPept AAH69670 AAH69820 AAH74734 AAI14617 AAQ10515 AAR22507 BAA78341 BAG37713 BAH14069 CAB62538 EAW78186

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca