Version 5.4
Bos taurus Protein: MSN
Summary
InnateDB Protein IDBP-689703.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MSN
Protein Name Moesin
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000017503
InnateDB Gene IDBG-637676 (MSN)
Protein Structure
UniProt Annotation
Function Probably involved in connections of major cytoskeletal structures to the plasma membrane. {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Apical cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cell projection, microvillus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Phosphorylated form is enriched in microvilli-like structures at apical membrane. Increased cell membrane localization of both phosphorylated and non-phosphorylated forms seen after thrombin treatment (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 44 interaction(s) predicted by orthology.
Predicted by orthology
Total 44 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003725 double-stranded RNA binding
GO:0003779 actin binding
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0008092 cytoskeletal protein binding
GO:0019901 protein kinase binding
GO:0050839 cell adhesion molecule binding
Biological Process
GO:0007159 leukocyte cell-cell adhesion
GO:0010628 positive regulation of gene expression
GO:0022614 membrane to membrane docking
GO:0050900 leukocyte migration
GO:0061028 establishment of endothelial barrier
GO:2000401 regulation of lymphocyte migration
Cellular Component
GO:0001931 uropod
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005902 microvillus
GO:0005925 focal adhesion
GO:0016020 membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0019898 extrinsic component of membrane
GO:0030175 filopodium
GO:0031528 microvillus membrane
GO:0042995 cell projection
GO:0045177 apical part of cell
GO:0070062 extracellular vesicular exosome
GO:0072562 blood microparticle
Protein Structure and Domains
PDB ID
InterPro IPR000299 FERM domain
IPR000798 Ezrin/radixin/moesin like
IPR008954 Moesin tail domain
IPR011174 Ezrin/radixin/moesin
IPR011259 Ezrin/radixin/moesin, C-terminal
IPR018979 FERM, N-terminal
IPR018980 FERM, C-terminal PH-like domain
IPR019748 FERM central domain
IPR019749 Band 4.1 domain
IPR019750 Band 4.1 family
IPR029071 Ubiquitin-related domain
PFAM PF00769
PF09379
PF09380
PF00373
PRINTS PR00661
PR00935
PIRSF PIRSF002305
SMART SM00295
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q2HJ49
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 540426
UniGene Bt.9207
RefSeq NP_001039942
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC113313
GenPept AAI13314

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca