Version 5.4
Bos taurus Protein: RBP4
Summary
InnateDB Protein IDBP-689754.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RBP4
Protein Name Retinol-binding protein 4
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000000566
InnateDB Gene IDBG-637726 (RBP4)
Protein Structure
UniProt Annotation
Function Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0005501 retinoid binding
GO:0005515 protein binding
GO:0016918 retinal binding
GO:0019841 retinol binding
GO:0034632 retinol transporter activity
GO:0036094 small molecule binding
Biological Process
GO:0001654 eye development
GO:0006094 gluconeogenesis
GO:0006810 transport
GO:0007283 spermatogenesis
GO:0007507 heart development
GO:0008584 male gonad development
GO:0030277 maintenance of gastrointestinal epithelium
GO:0030324 lung development
GO:0032024 positive regulation of insulin secretion
GO:0032526 response to retinoic acid
GO:0032868 response to insulin
GO:0034633 retinol transport
GO:0042572 retinol metabolic process
GO:0042574 retinal metabolic process
GO:0042593 glucose homeostasis
GO:0048562 embryonic organ morphogenesis
GO:0048706 embryonic skeletal system development
GO:0048738 cardiac muscle tissue development
GO:0048807 female genitalia morphogenesis
GO:0050908 detection of light stimulus involved in visual perception
GO:0051024 positive regulation of immunoglobulin secretion
GO:0060041 retina development in camera-type eye
GO:0060044 negative regulation of cardiac muscle cell proliferation
GO:0060059 embryonic retina morphogenesis in camera-type eye
GO:0060065 uterus development
GO:0060068 vagina development
GO:0060157 urinary bladder development
GO:0060347 heart trabecula formation
Cellular Component
GO:0005576 extracellular region
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000566 Lipocalin/cytosolic fatty-acid binding domain
IPR002345 Lipocalin
IPR002449 Retinol binding protein/Purpurin
IPR003057 Invertebrate colouration protein
IPR011038 Calycin-like
IPR022271 Lipocalin, ApoD type
PFAM PF00061
PF08212
PRINTS PR00179
PR01174
PR01273
PIRSF PIRSF500204
PIRSF036893
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P18902
PhosphoSite PhosphoSite-
TrEMBL G1K122
UniProt Splice Variant
Entrez Gene 281444
UniGene
RefSeq NP_001035565
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02058833 S65585
GenPept AAB28336

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca