InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: RBP4

Summary

InnateDB Gene

IDBG-637726.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RBP4

Gene Name

Retinol-binding protein 4

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000000442

Encoded Proteins

IDBP-689754

Retinol-binding protein 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000138207:
This protein belongs to the lipocalin family and is the specific carrier for retinol (vitamin A alcohol) in the blood. It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin which prevents its loss by filtration through the kidney glomeruli. A deficiency of vitamin A blocks secretion of the binding protein posttranslationally and results in defective delivery and supply to the epidermal cells. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 26:14940551-14946750

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000000566

ENSBTAP00000000566

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005501	retinoid binding
GO:0005515	protein binding
GO:0016918	retinal binding
GO:0019841	retinol binding
GO:0034632	retinol transporter activity
GO:0036094	small molecule binding

Biological Process

GO:0001654	eye development
GO:0006094	gluconeogenesis
GO:0006810	transport
GO:0007283	spermatogenesis
GO:0007507	heart development
GO:0008584	male gonad development
GO:0030277	maintenance of gastrointestinal epithelium
GO:0030324	lung development
GO:0032024	positive regulation of insulin secretion
GO:0032526	response to retinoic acid
GO:0032868	response to insulin
GO:0034633	retinol transport
GO:0042572	retinol metabolic process
GO:0042574	retinal metabolic process
GO:0042593	glucose homeostasis
GO:0048562	embryonic organ morphogenesis
GO:0048706	embryonic skeletal system development
GO:0048738	cardiac muscle tissue development
GO:0048807	female genitalia morphogenesis
GO:0050908	detection of light stimulus involved in visual perception
GO:0051024	positive regulation of immunoglobulin secretion
GO:0060041	retina development in camera-type eye
GO:0060044	negative regulation of cardiac muscle cell proliferation
GO:0060059	embryonic retina morphogenesis in camera-type eye
GO:0060065	uterus development
GO:0060068	vagina development
GO:0060157	urinary bladder development
GO:0060347	heart trabecula formation