Version 5.4
Bos taurus Protein: PIGK
Summary
InnateDB Protein IDBP-689756.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PIGK
Protein Name GPI-anchor transamidase
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000041428
InnateDB Gene IDBG-637728 (PIGK)
Protein Structure
UniProt Annotation
Function Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein (By similarity). {ECO:0000250}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003923 GPI-anchor transamidase activity
GO:0004197 cysteine-type endopeptidase activity
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0008234 cysteine-type peptidase activity
GO:0016787 hydrolase activity
Biological Process
GO:0006506 GPI anchor biosynthetic process
GO:0006508 proteolysis
GO:0016255 attachment of GPI anchor to protein
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0042765 GPI-anchor transamidase complex
Protein Structure and Domains
PDB ID
InterPro IPR001096 Peptidase C13, legumain
PFAM PF01650
PRINTS PR00776
PIRSF PIRSF019663
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3MHZ7
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 508700
UniGene Bt.67221
RefSeq NP_001071348
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC104506
GenPept AAI04507

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca