InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PPP1R3B

Summary

InnateDB Protein

IDBP-6899.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PPP1R3B

Protein Name

protein phosphatase 1, regulatory subunit 3B

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000308318

InnateDB Gene

IDBG-6897 (PPP1R3B)

Protein Structure

UniProt Annotation

Function

Acts as a glycogen-targeting subunit for phosphatase PP1. Facilitates interaction of the PP1 with enzymes of the glycogen metabolism and regulates its activity. Suppresses the rate at which PP1 dephosphorylates (inactivates) glycogen phosphorylase and enhances the rate at which it activates glycogen synthase and therefore limits glycogen breakdown. Its activity is inhibited by PYGL, resulting in inhibition of the glycogen synthase and glycogen phosphorylase phosphatase activities of PP1. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in hepatocytes (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Highly expressed in the liver and, at lower levels, in skeletal muscle, including in vastus lateralis, gastrocnemius and soleus (at protein level). Highest mRNA levels are observed in skeletal muscle, and only moderate levels in liver and heart. Weak expression in placenta and lung. {ECO:0000269PubMed:11872655, ECO:0000269PubMed:17555403}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004721	phosphoprotein phosphatase activity
GO:0005515	protein binding
GO:0019888	protein phosphatase regulator activity
GO:0019899	enzyme binding

Biological Process

GO:0005977	glycogen metabolic process
GO:0005979	regulation of glycogen biosynthetic process
GO:0005981	regulation of glycogen catabolic process
GO:0016311	dephosphorylation
GO:0050790	regulation of catalytic activity