InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: UBE2L6

Summary

InnateDB Protein

IDBP-689910.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UBE2L6

Protein Name

Ubiquitin/ISG15-conjugating enzyme E2 L6

Synonyms

UbcM8;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000017267

InnateDB Gene

IDBG-637879 (UBE2L6)

Protein Structure

UniProt Annotation

Function

Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3 (By similarity). {ECO:0000255PROSITE- ProRule:PRU00388}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 35 interaction(s) predicted by orthology.

Predicted by orthology
Total	35 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016874	ligase activity
GO:0016881	acid-amino acid ligase activity
GO:0019787	small conjugating protein ligase activity
GO:0042296	ISG15 ligase activity

Biological Process

GO:0016567	protein ubiquitination
GO:0019941	modification-dependent protein catabolic process
GO:0032020	ISG15-protein conjugation

Cellular Component

Protein Structure and Domains

PDB ID

InterPro

IPR000608 Ubiquitin-conjugating enzyme, E2
IPR016135 Ubiquitin-conjugating enzyme/RWD-like

PFAM

PF00179

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

A5PJC4

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

509471

UniGene

Bt.10807

RefSeq

NP_001092387

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC142048

GenPept

AAI42049