InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: UBE2L6

Summary

InnateDB Gene

IDBG-637879.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UBE2L6

Gene Name

Ubiquitin/ISG15-conjugating enzyme E2 L6

Synonyms

UbcM8

Species

Bos taurus

Ensembl Gene

ENSBTAG00000012989

Encoded Proteins

IDBP-689910

Ubiquitin/ISG15-conjugating enzyme E2 L6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000156587:
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is highly similar in primary structure to the enzyme encoded by the UBE2L3 gene. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:82124876-82138170

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000017267

ENSBTAP00000017267

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 35 interaction(s) predicted by orthology.

Predicted by orthology
Total	35 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016874	ligase activity
GO:0016881	acid-amino acid ligase activity
GO:0019787	small conjugating protein ligase activity
GO:0042296	ISG15 ligase activity