Version 5.4
Bos taurus Protein: PTGER3
Summary
InnateDB Protein IDBP-689962.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTGER3
Protein Name Prostaglandin E2 receptor EP3 subtype
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000025607
InnateDB Gene IDBG-637924 (PTGER3)
Protein Structure
UniProt Annotation
Function Receptor for prostaglandin E2 (PGE2); the EP3 receptor may be involved in inhibition of gastric acid secretion, modulation of neurotransmitter release in central and peripheral neurons, inhibition of sodium and water reabsorption in kidney tubulus and contraction in uterine smooth muscle. The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G-I proteins, and to an elevation of intracellular calcium. The various isoforms have identical ligand binding properties but interact with different second messenger systems: isoform EP3A couples to G(i)/G(o) proteins; isoform EP3B and isoform EP3C couple to G(s), and isoform EP3D couples to G(i), G(s) and G(p).
Subcellular Localization Cell membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0004955 prostaglandin receptor activity
GO:0004957 prostaglandin E receptor activity
GO:0005515 protein binding
Biological Process
GO:0001660 fever generation
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0015701 bicarbonate transport
GO:0032496 response to lipopolysaccharide
GO:0035810 positive regulation of urine volume
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000265 Prostanoid EP3 receptor
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR001105 Thromboxane receptor
IPR001244 Prostaglandin DP receptor
IPR001481 Prostanoid EP3 receptor, type 2
IPR008365 Prostanoid receptor
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019420 7TM GPCR, serpentine receptor class bc (Srbc)
IPR019430 7TM GPCR, serpentine receptor class x (Srx)
PFAM PF00001
PF10316
PF10328
PRINTS PR00582
PR00237
PR00429
PR00428
PR00584
PR01788
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P34979
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 282330
UniGene
RefSeq NP_851375
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL D21345 D21346 D21347 D21348
GenPept BAA04811 BAA04812 BAA04813 BAA04814

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca