InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: PTGER3

Summary

InnateDB Gene

IDBG-637924.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PTGER3

Gene Name

Prostaglandin E2 receptor EP3 subtype

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000019230

Encoded Proteins

IDBP-689962

Prostaglandin E2 receptor EP3 subtype

IDBP-689965

Prostaglandin E2 receptor EP3 subtype

IDBP-689968

Prostaglandin E2 receptor EP3 subtype

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000050628:
The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor may have many biological functions, which involve digestion, nervous system, kidney reabsorption, and uterine contraction activities. Studies of the mouse counterpart suggest that this receptor may also mediate adrenocorticotropic hormone response as well as fever generation in response to exogenous and endogenous stimuli. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:74488314-74530201

Strand

Forward strand

Band

Transcripts

ENSBTAT00000025607	ENSBTAP00000025607
ENSBTAT00000064347	ENSBTAP00000056165
ENSBTAT00000064398	ENSBTAP00000054348

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0004930	G-protein coupled receptor activity
GO:0004955	prostaglandin receptor activity
GO:0004957	prostaglandin E receptor activity
GO:0005515	protein binding

Biological Process

GO:0001660	fever generation
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0015701	bicarbonate transport
GO:0032496	response to lipopolysaccharide
GO:0035810	positive regulation of urine volume