Version 5.4
| Bos taurus Protein: PTGER3 | |||||||||||
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| Summary | |||||||||||
| InnateDB Protein | IDBP-689965.3 | ||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||
| Gene Symbol | PTGER3 | ||||||||||
| Protein Name | Prostaglandin E2 receptor EP3 subtype | ||||||||||
| Synonyms | |||||||||||
| Species | Bos taurus | ||||||||||
| Ensembl Protein | ENSBTAP00000056165 | ||||||||||
| InnateDB Gene | IDBG-637924 (PTGER3) | ||||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||||
| Function | Receptor for prostaglandin E2 (PGE2); the EP3 receptor may be involved in inhibition of gastric acid secretion, modulation of neurotransmitter release in central and peripheral neurons, inhibition of sodium and water reabsorption in kidney tubulus and contraction in uterine smooth muscle. The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G-I proteins, and to an elevation of intracellular calcium. The various isoforms have identical ligand binding properties but interact with different second messenger systems: isoform EP3A couples to G(i)/G(o) proteins; isoform EP3B and isoform EP3C couple to G(s), and isoform EP3D couples to G(i), G(s) and G(p). | ||||||||||
| Subcellular Localization | Cell membrane; Multi-pass membrane protein. | ||||||||||
| Disease Associations | |||||||||||
| Tissue Specificity | |||||||||||
| Comments | |||||||||||
| Interactions | |||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||||
| PDB ID | |||||||||||
| InterPro |
IPR000265
Prostanoid EP3 receptor IPR000276 G protein-coupled receptor, rhodopsin-like IPR001105 Thromboxane receptor IPR001244 Prostaglandin DP receptor IPR001481 Prostanoid EP3 receptor, type 2 IPR008365 Prostanoid receptor IPR017452 GPCR, rhodopsin-like, 7TM IPR019420 7TM GPCR, serpentine receptor class bc (Srbc) IPR019430 7TM GPCR, serpentine receptor class x (Srx) |
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| PFAM |
PF00001
PF10316 PF10328 |
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| PRINTS |
PR00582
PR00237 PR00429 PR00428 PR00584 PR01788 |
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| PIRSF | |||||||||||
| SMART | |||||||||||
| TIGRFAMs | |||||||||||
| Post-translational Modifications | |||||||||||
| Modification | |||||||||||
| Cross-References | |||||||||||
| SwissProt | P34979 | ||||||||||
| PhosphoSite | PhosphoSite- | ||||||||||
| TrEMBL | |||||||||||
| UniProt Splice Variant | |||||||||||
| Entrez Gene | 282330 | ||||||||||
| UniGene | |||||||||||
| RefSeq | XP_005204499 | ||||||||||
| HUGO | |||||||||||
| OMIM | |||||||||||
| CCDS | |||||||||||
| HPRD | |||||||||||
| IMGT | |||||||||||
| EMBL | D21345 D21346 D21347 D21348 | ||||||||||
| GenPept | BAA04811 BAA04812 BAA04813 BAA04814 | ||||||||||