Version 5.4
Bos taurus Protein: SLC35D2
Summary
InnateDB Protein IDBP-690171.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC35D2
Protein Name UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter
Synonyms SLC35D2;
Species Bos taurus
Ensembl Protein ENSBTAP00000007164
InnateDB Gene IDBG-638130 (SLC35D2)
Protein Structure
UniProt Annotation
Function Antiporter transporting nucleotide sugars such as UDP-N- acetylglucosamine (UDP-GlcNAc), UDP-glucose (UDP-Glc) and GDP- mannose (GDP-Man) pooled in the cytosol into the lumen of the Golgi in exchange for the corresponding nucleosides monophosphates (UMP for UDP-sugars and GMP for GDP-sugars). May take part in heparan sulfate synthesis by supplying UDP-GlcNAc, the donor substrate, and thus be involved in growth factor signaling (By similarity). {ECO:0000250}.
Subcellular Localization Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity
Biological Process
GO:0006810 transport
GO:0008643 carbohydrate transport
GO:0015781 pyrimidine nucleotide-sugar transport
GO:0030206 chondroitin sulfate biosynthetic process
GO:0048706 embryonic skeletal system development
GO:0090481 pyrimidine nucleotide-sugar transmembrane transport
Cellular Component
GO:0000139 Golgi membrane
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR004853 Triose-phosphate transporter domain
PFAM PF03151
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A2VE55
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 613734
UniGene Bt.58895
RefSeq NP_001075928
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC133580
GenPept AAI33581

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca