InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: TAF1B

Summary

InnateDB Protein

IDBP-690374.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TAF1B

Protein Name

TATA box-binding protein-associated factor RNA polymerase I subunit B

Synonyms

TAFI63;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000041230

InnateDB Gene

IDBG-638300 (TAF1B)

Protein Structure

UniProt Annotation

Function

Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during trancription initiation such as preinitiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment as a component of the SL1/TIF-IB complex and, possibly, directly through its interaction with RRN3 (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus, nucleolus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001164	RNA polymerase I CORE element sequence-specific DNA binding
GO:0001187	RNA polymerase I CORE element sequence-specific DNA binding transcription factor recruiting transcription factor activity
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0001189	RNA polymerase I transcriptional preinitiation complex assembly at the promoter for the nuclear large rRNA transcript
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated