Version 5.4
Bos taurus Gene: TAF1B
Summary
InnateDB Gene IDBG-638300.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TAF1B
Gene Name TATA box-binding protein-associated factor RNA polymerase I subunit B
Synonyms TAFI63
Species Bos taurus
Ensembl Gene ENSBTAG00000007543
Encoded Proteins
IDBP-690374
TATA box-binding protein-associated factor RNA polymerase I subunit B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115750:
Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes one of the SL1-specific TAFs. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:87633914-87689585
Strand Reverse strand
Band
Transcripts
ENSBTAT00000043676 ENSBTAP00000041230
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Predicted by orthology
Total 18 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001164 RNA polymerase I CORE element sequence-specific DNA binding
GO:0001187 RNA polymerase I CORE element sequence-specific DNA binding transcription factor recruiting transcription factor activity
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0001189 RNA polymerase I transcriptional preinitiation complex assembly at the promoter for the nuclear large rRNA transcript
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0070062 extracellular vesicular exosome
GO:0070860 RNA polymerase I core factor complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000115750
View Gene Order
ENSMUSG00000059669
View Gene Order
Pathways
NETPATH
REACTOME
REACT_221445
RNA Polymerase I Transcription Termination pathway
REACT_217942
SIRT1 negatively regulates rRNA Expression pathway
REACT_213048
Epigenetic regulation of gene expression pathway
REACT_203707
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
REACT_217354
RNA Polymerase I Promoter Escape pathway
REACT_207088
RNA Polymerase I Transcription pathway
REACT_226022
Gene Expression pathway
REACT_225163
RNA Polymerase I Chain Elongation pathway
REACT_208197
RNA Polymerase I Transcription Initiation pathway
REACT_215001
Negative epigenetic regulation of rRNA expression pathway
REACT_219488
RNA Polymerase I Promoter Clearance pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_1074
RNA Polymerase I Transcription Termination pathway
REACT_2204
RNA Polymerase I Chain Elongation pathway
REACT_1913
RNA Polymerase I Promoter Escape pathway
REACT_953
RNA Polymerase I Transcription Initiation pathway
REACT_1309
RNA Polymerase I Transcription pathway
REACT_200857
Epigenetic regulation of gene expression pathway
REACT_1974
RNA Polymerase I Promoter Clearance pathway
REACT_200856
NoRC negatively regulates rRNA expression pathway
REACT_200827
SIRT1 negatively regulates rRNA Expression pathway
REACT_21352
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
REACT_71
Gene Expression pathway
REACT_200834
Negative epigenetic regulation of rRNA expression pathway
REACT_245058
RNA Polymerase I Transcription pathway
REACT_244415
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
REACT_257165
RNA Polymerase I Transcription Termination pathway
REACT_205737
Epigenetic regulation of gene expression pathway
REACT_224328
SIRT1 negatively regulates rRNA Expression pathway
REACT_233572
Gene Expression pathway
REACT_207809
Negative epigenetic regulation of rRNA expression pathway
REACT_232235
RNA Polymerase I Promoter Escape pathway
REACT_240511
RNA Polymerase I Promoter Clearance pathway
REACT_259097
RNA Polymerase I Chain Elongation pathway
REACT_235780
RNA Polymerase I Transcription Initiation pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q1JQD6
TrEMBL
UniProt Splice Variant
Entrez Gene 511236
UniGene Bt.20695
RefSeq NM_001075503
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AAFC03016422 AAFC03016423 AAFC03016426 AAFC03034356 AAFC03034357 BC116032 DAAA02031936 DAAA02031937
GenPept AAI16033
RNA Seq Atlas 511236

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca