InnateDB Protein
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IDBP-690376.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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LEPROT
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Protein Name
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Leptin receptor gene-related protein
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Synonyms
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OB-RGRP;
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Species
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Bos taurus
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Ensembl Protein
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ENSBTAP00000007762
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InnateDB Gene
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IDBG-638313 (LEPROT)
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Protein Structure
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Function |
Negatively regulates leptin receptor (LEPR) cell surface expression, and thus decreases response to leptin/LEP. Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability (By similarity). {ECO:0000250}.
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Subcellular Localization |
Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endosome membrane {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR007262
Vacuolar protein sorting 55
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PFAM |
PF04133
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q3SYT0
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
613665
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UniGene |
Bt.20776
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RefSeq |
NP_001029913
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HUGO |
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
BC103409
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GenPept |
AAI03410
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