InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: DNM1L

Summary

InnateDB Protein

IDBP-690428.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DNM1L

Protein Name

Dynamin-1-like protein

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000037777

InnateDB Gene

IDBG-638362 (DNM1L)

Protein Structure

UniProt Annotation

Function

Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into membrane- associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism. Through its function in mitochondrial division, ensures the survival of at least some types of postmitotic neurons, including Purkinje cells, by suppressing oxidative damage. Required for normal brain development, including that of cerebellum. Facilitates developmentally regulated apoptosis during neural tube formation. Required for a normal rate of cytochrome c release and caspase activation during apoptosis; this requirement may depend upon the cell type and the physiological apoptotic cues. Also required for mitochondrial fission during mitosis. Required for formation of endocytic vesicles. Proposed to regulate synaptic vesicle membrane dynamics through association with BCL2L1 isoform Bcl-X(L) which stimulates its GTPase activity in synaptic vesicles; the function may require its recruitment by MFF to clathrin-containing vesicles. Required for programmed necrosis execution (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytosol {ECO:0000250}. Golgi apparatus {ECO:0000250}. Endomembrane system; Peripheral membrane protein. Mitochondrion outer membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Peroxisome {ECO:0000250}. Membrane, clathrin-coated pit {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250}. Note=Mainly cytosolic. Translocated to the mitochondrial membrane through O-GlcNAcylation and interaction with FIS1. Colocalized with MARCH5 at mitochondrial membrane. Localizes to mitochondria at sites of division. Localizes to mitochondria following necrosis induction. Associated with peroxisomal membranes, partly recruited there by PEX11B. May also be associated with endoplasmic reticulum tubules and cytoplasmic vesicles and found to be perinuclear. In some cell types, localizes to the Golgi complex. Binds to phospholipid membranes (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0008289	lipid binding
GO:0016787	hydrolase activity
GO:0031625	ubiquitin protein ligase binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0000266	mitochondrial fission
GO:0001836	release of cytochrome c from mitochondria
GO:0003374	dynamin polymerization involved in mitochondrial fission
GO:0006184	GTP catabolic process
GO:0006897	endocytosis
GO:0010821	regulation of mitochondrion organization
GO:0012501	programmed cell death
GO:0016559	peroxisome fission
GO:0032459	regulation of protein oligomerization
GO:0043065	positive regulation of apoptotic process
GO:0043653	mitochondrial fragmentation involved in apoptotic process
GO:0050714	positive regulation of protein secretion
GO:0051289	protein homotetramerization
GO:0061025	membrane fusion
GO:0070266	necroptotic process
GO:0070584	mitochondrion morphogenesis
GO:0070585	protein localization to mitochondrion
GO:0090149	membrane fission involved in mitochondrial fission
GO:0090200	positive regulation of release of cytochrome c from mitochondria
GO:1900063	regulation of peroxisome organization
GO:2001244	positive regulation of intrinsic apoptotic signaling pathway

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0005777	peroxisome
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0005874	microtubule
GO:0005905	coated pit
GO:0012505	endomembrane system
GO:0016020	membrane
GO:0030054	cell junction
GO:0030672	synaptic vesicle membrane
GO:0031410	cytoplasmic vesicle
GO:0043231	intracellular membrane-bounded organelle
GO:0043234	protein complex
GO:0045202	synapse
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000375 Dynamin central domain
IPR001401 Dynamin, GTPase domain
IPR003130 Dynamin GTPase effector
IPR022812 Dynamin superfamily
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF01031
PF00350
PF02212

PRINTS

PR00195

PIRSF

SMART

SM00053
SM00302

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q2KIA5

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

540892

UniGene

Bt.87451

RefSeq

NP_001039959

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC112710

GenPept

AAI12711