Version 5.4
Bos taurus Gene: DNM1L
Summary
InnateDB Gene IDBG-638362.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DNM1L
Gene Name Dynamin-1-like protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000011395
Encoded Proteins
IDBP-690428
Dynamin-1-like protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 24733894
[Homo sapiens] Hepatitis C infection stimulates the expression of DNM1L and MFF and promotes DNM1L recruitment to mitochondria by stimulating the phosphorylation of DNM1L, leading to mitochondrial fission.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000087470:
The protein encoded by this gene is a member of the dynamin superfamily of GTPases. Members of the dynamin-related subfamily, including the S. cerevisiae proteins Dnm1 and Vps1, contain the N-terminal tripartite GTPase domain but do not have the pleckstrin homology or proline-rich domains. This protein establishes mitochondrial morphology through a role in distributing mitochondrial tubules throughout the cytoplasm. The gene has 3 alternatively spliced transcripts encoding different isoforms. These transcripts are alternatively polyadenylated. [provided by RefSeq, Jul 2008]
This gene encodes a member of the dynamin superfamily of GTPases. The encoded protein mediates mitochondrial and peroxisomal division, and is involved in developmentally regulated apoptosis and programmed necrosis. Dysfunction of this gene is implicated in several neurological disorders, including Alzheimer\'s disease. Mutations in this gene are associated with the autosomal dominant disorder, encephalopathy, lethal, due to defective mitochondrial and peroxisomal fission (EMPF). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:77514854-77575339
Strand Reverse strand
Band
Transcripts
ENSBTAT00000037956 ENSBTAP00000037777
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.
Predicted by orthology
Total 22 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0008289 lipid binding
GO:0016787 hydrolase activity
GO:0031625 ubiquitin protein ligase binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0000266 mitochondrial fission
GO:0001836 release of cytochrome c from mitochondria
GO:0003374 dynamin polymerization involved in mitochondrial fission
GO:0006184 GTP catabolic process
GO:0006897 endocytosis
GO:0010821 regulation of mitochondrion organization
GO:0012501 programmed cell death
GO:0016559 peroxisome fission
GO:0032459 regulation of protein oligomerization
GO:0043065 positive regulation of apoptotic process
GO:0043653 mitochondrial fragmentation involved in apoptotic process
GO:0050714 positive regulation of protein secretion
GO:0051289 protein homotetramerization
GO:0061025 membrane fusion
GO:0070266 necroptotic process
GO:0070584 mitochondrion morphogenesis
GO:0070585 protein localization to mitochondrion
GO:0090149 membrane fission involved in mitochondrial fission
GO:0090200 positive regulation of release of cytochrome c from mitochondria
GO:1900063 regulation of peroxisome organization
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005777 peroxisome
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005874 microtubule
GO:0005905 coated pit
GO:0012505 endomembrane system
GO:0016020 membrane
GO:0030054 cell junction
GO:0030672 synaptic vesicle membrane
GO:0031410 cytoplasmic vesicle
GO:0043231 intracellular membrane-bounded organelle
GO:0043234 protein complex
GO:0045202 synapse
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000087470
View Gene Order
ENSMUSG00000022789
View Gene Order
Pathways
NETPATH
REACTOME
REACT_227007
Apoptotic execution phase pathway
REACT_219454
Apoptosis pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_995
Apoptotic execution phase pathway
REACT_578
Apoptosis pathway
REACT_258521
Apoptosis pathway
REACT_207035
Apoptotic execution phase pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.87451
RefSeq NM_001046494
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca