Version 5.4
Bos taurus Protein: IRF6
Summary
InnateDB Protein IDBP-690430.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IRF6
Protein Name Interferon regulatory factor 6
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000003694
InnateDB Gene IDBG-638354 (IRF6)
Protein Structure
UniProt Annotation
Function Probable DNA-binding transcriptional activator. It is a key determinant of the keratinocyte proliferation-differentiation switch involved in appropriate epidermal development. Plays a role in regulating mammary epithelial cell proliferation (By similarity). May regulate WDR65 transcription (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000305}. Cytoplasm {ECO:0000250}. Note=Translocates to nucleus in response to an activating signal. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000975 regulatory region DNA binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0008285 negative regulation of cell proliferation
GO:0030154 cell differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0060644 mammary gland epithelial cell differentiation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR001346 Interferon regulatory factor DNA-binding domain
IPR008984 SMAD/FHA domain
IPR019471 Interferon regulatory factor-3
PFAM PF00605
PF10401
PRINTS PR00267
PIRSF
SMART SM00348
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q08DD6
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 614253
UniGene Bt.28192
RefSeq NP_001070402
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC123806
GenPept AAI23807

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca