InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: IRF6

Summary

InnateDB Gene

IDBG-638354.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IRF6

Gene Name

Interferon regulatory factor 6

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000002849

Encoded Proteins

IDBP-690427

Interferon regulatory factor 6

IDBP-690430

Interferon regulatory factor 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 12219090

[Homo sapiens] IRF6 belongs to a family of transcription factors that share a highly conserved helix-turn-helix DNA-binding domain and a less conserved protein-binding domain.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000117595:
This gene encodes a member of the interferon regulatory transcription factor (IRF) family. Family members share a highly-conserved N-terminal helix-turn-helix DNA-binding domain and a less conserved C-terminal protein-binding domain. The encoded protein may be a transcriptional activator. Mutations in this gene can cause van der Woude syndrome and popliteal pterygium syndrome. Mutations in this gene are also associated with non-syndromic orofacial cleft type 6. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:75401221-75417466

Strand

Forward strand

Band

Transcripts

ENSBTAT00000065312	ENSBTAP00000054388
ENSBTAT00000003694	ENSBTAP00000003694

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000975	regulatory region DNA binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007050	cell cycle arrest
GO:0008285	negative regulation of cell proliferation
GO:0030154	cell differentiation
GO:0030216	keratinocyte differentiation
GO:0043588	skin development
GO:0043616	keratinocyte proliferation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0048468	cell development
GO:0060644	mammary gland epithelial cell differentiation