InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: SFRP5

Summary

InnateDB Protein

IDBP-690545.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SFRP5

Protein Name

Secreted frizzled-related protein 5

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000024709

InnateDB Gene

IDBG-638478 (SFRP5)

Protein Structure

UniProt Annotation

Function

Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP5 may be involved in determining the polarity of photoreceptor, and perhaps other, cells in the retina. Inhibits Wnt8 signaling, in vitro.

Subcellular Localization

Secreted {ECO:0000305}.

Disease Associations

Tissue Specificity

Strongly expressed in the retinal pigment epithelium (RPE). Weak expression in retina, brain, heart, liver, kidney, testis and muscle. {ECO:0000269PubMed:10072424}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0017147	Wnt-protein binding
GO:0030165	PDZ domain binding
GO:0042813	Wnt-activated receptor activity

Biological Process

GO:0001944	vasculature development
GO:0007275	multicellular organismal development
GO:0007420	brain development
GO:0008285	negative regulation of cell proliferation
GO:0008406	gonad development
GO:0016055	Wnt signaling pathway
GO:0030154	cell differentiation
GO:0030178	negative regulation of Wnt signaling pathway
GO:0035414	negative regulation of catenin import into nucleus
GO:0036342	post-anal tail morphogenesis
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043508	negative regulation of JUN kinase activity
GO:0048546	digestive tract morphogenesis
GO:0051898	negative regulation of protein kinase B signaling
GO:0060028	convergent extension involved in axis elongation
GO:0060070	canonical Wnt signaling pathway
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:0090175	regulation of establishment of planar polarity
GO:0090179	planar cell polarity pathway involved in neural tube closure
GO:2000041	negative regulation of planar cell polarity pathway involved in axis elongation
GO:2000057	negative regulation of Wnt receptor signaling pathway involved in digestive tract morphogenesis

Cellular Component

GO:0005576	extracellular region
GO:0005737	cytoplasm
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001134 Netrin domain
IPR008993 Tissue inhibitor of metalloproteinases-like, OB-fold
IPR018933 Netrin module, non-TIMP type
IPR020067 Frizzled domain

PFAM

PF01759
PF01392

PRINTS

PIRSF

SMART

SM00643
SM00063

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9XSC1